Division of Molecular and Cellular Biosciences Core Programs
NSF funds basic research on fundamental molecular, cellular, genetic, and systems biology in U.S. higher education and eligible nonprofit research organizations.
⚑ Research focused exclusively on human disease and treatment is normally outside scope and may be returned without review. · International branch campus funding requires justification that the work cannot be done at the U.S. campus.
Unit fits — one characterization, each unit's own rules
| Physical Sciences & Engineering (demo) | 80 strong | technical depth: substantial; funds basic research |
| IPPRA | 40 partial | outside portfolio topics; social/behavioral work is none; funds basic research; biomedical core — IPPRA health lane is communication/crisis/policy (capped) |
| Tom Love Innovation Hub | 15 none | deep-tech content; no commercialization signal |
Description
MCB supports research that promises to uncover the fundamental properties of living systems across atomic, molecular, subcellular, and cellular scales. The program gives high priority to projects that advance mechanistic understanding of the structure, function, and evolution of molecular, subcellular, and cellular systems, especially research that aims at quantitative and predictive knowledge of complex behavior and emergent properties. MCB encourages research exploring new concepts in molecular and cellular biology, while incorporating insights and approaches from other scientific disciplines, such as chemistry, computer science, engineering, mathematics, and physics, to illuminate principles that govern life at the molecular and cellular level. MCB also encourages research that exploits experimental and theoretical approaches and utilizes a diverse spectrum of model and non-model animals, plants, and microbes across the tree of life. Proposals that pursue potentially transformative ideas are welcome, even if these entail higher risk.
This solicitation calls for proposals in research areas supported by the four MCB core clusters, including: (i) structure, dynamics, and function of biomolecules and supramolecular assemblies, especially under physiological conditions ( Molecular Biophysics ); (ii) organization, processing, expression, regulation, and evolution of genetic and epigenetic information ( Genetic Mechanisms ); (iii) cellular structure, properties, and function across broad spatiotemporal scales ( Cellular Dynamics and Function ); and (iv) systems and/or synthetic biology to study complex interactions through modeling or manipulation or design of living systems at the molecular-to-cellular scale ( Systems and Synthetic Biology ). All MCB clusters prioritize projects that integrate across scales, investigate molecular and cellular evolution, synergize experimental research with computational or mathematical modeling, and/or develop innovative, broadly applicable methods and technologies. Projects that bridge the intellectual edges between MCB clusters are welcome. Projects that integrate molecular and cellular biosciences with other subdisciplines of biology are also welcome through the new Integrative Research in Biology (IntBIO) track.
Regarding health-related challenges, NSF supports basic research in all areas of the biological sciences and recognizes that this foundational research is likely to impact many different areas, including human health. MCB celebrates all the biological science discoveries funded through MCB awards that have had major impacts on health, environment, energy, food production, and other applications. Nevertheless, research focused exclusively on understanding human diseases and their treatment is normally outside of the scope offunding and will be returned without review unless that research significantly advances other fields such as engineering, computer science, or the mathematical and physical sciences.
Eligibility
*Who May Submit Proposals: Proposals may only be submitted by the following: -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities. -Institutions of Higher Education (IHEs): Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of sub-awards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus.
Apply
View on Grants.gov → CONTACT: U.S. National Science Foundation <grantsgovsupport@nsf.gov>
Proposal brief SEE AN EXAMPLE →
A one-page internal memo: fit assessment, submission requirements, document scaffold, and next steps dated back from the deadline — tailored to your project idea if you add one.
Proposal shell · National Science Foundation conventions SEE AN NSF EXAMPLE →
Funder-faithful document skeletons — National Science Foundation's document set with section headings, page limits, reviewer guidance, and writing prompts; add a project idea to get [DRAFT] starter bullets. Download as .md for Word or Overleaf.