Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative UG3/UH3 Clinical Trial Required)
Funds a cooperative-agreement clinical coordinating center to plan and run a fully powered multi-site investigator-initiated mind-and-body intervention clinical trial for eligible applicants, with a separate required data coordinating center application.
⚑ UG3/UH3 two-phase milestone-driven cooperative agreement · Separate DCC (U24) under PAR-24-087 required and must be submitted simultaneously · Foreign organizations are listed as eligible in the notice text, but non-domestic components of U.S. organizations are not eligible · NCCIH prior-contact encouragement for scientific/research area
Unit fits — one characterization, each unit's own rules
| Physical Sciences & Engineering (demo) | 70 strong | technical depth: substantial; funds applied research |
| IPPRA | 58 good | portfolio topics: public_health, mental_behavioral_health; social/behavioral work is substantial; funds applied research; clinical-trial/biomedical core — IPPRA angle is policy/community (capped) |
| Tom Love Innovation Hub | 30 weak | funds applied research; deep-tech content |
Description
This notice of funding opportunity (NOFO) encourages applications for investigator-initiated multi site clinical trials (e.g., efficacy, effectiveness, or pragmatic trials) to study the effects of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions), and/or multicomponent interventions that include physical, psychological, and/or nutritional approaches in NCCIH- designated areas of high research priority. Clinical Coordinating Centers (CCC) should develop and implement the proposed fully powered multi-site clinical trial (Phase III and beyond). The objective of a CCC application is to present the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. CCC applications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. CCC applications submitted under this NOFO will utilize a two-phase, milestone-driven cooperative agreement (UG3/UH3) funding mechanism. In addition, an accompanying Data Coordinating Center (DCC) application (U24), submitted under PAR-24-087 proposing a data analysis and data management plan for the clinical project is required. Both a CCC application and a corresponding DCC application need to be submitted simultaneously for consideration by NCCIH. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website: (https://nccih.nih.gov/about/plans). Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Apply
View on Grants.gov → CONTACT: National Institutes of Health <grantsinfo@nih.gov>
Proposal brief
Proposal shell · National Institutes of Health conventions
Legacy IPPRA LLM assessment (v2.0, for comparison)
18/100 · gpt-5.4-mini · 2026-07-06
This is an NIH clinical trial coordinating-center opportunity for mind-body interventions, which is squarely in health research but not in IPPRA’s core strengths of policy, behavior, risk communication, or population survey infrastructure. The work is operational and clinical-trial management rather than a social-science or public-policy research question, so IPPRA would be at best a peripheral partner. Public universities are eligible, but the fit to IPPRA’s portfolio is weak and should be capped low.
Legacy scoring history
| 2026-07-06 | 18 | gpt-5.4-mini | This is an NIH clinical trial coordinating-center opportunity for mind-body interventions, which is squarely in health research but not in IPPRA’s core strengths of policy, behavior, risk communication, or population survey infrastructure. The work is operational and clinical-trial management rather than a social-science or public-policy research question, so IPPRA would be at best a peripheral partner. Public universities are eligible, but the fit to IPPRA’s portfolio is weak and should be capped low. |
| 2026-07-06 | 18 | gpt-5.4-mini | This is a clinical trial coordination opportunity for mind-body and complementary health interventions, which is adjacent to IPPRA only in the broad sense of behavioral/health-related research. It does not center on public policy, risk communication, or community decision-making, so the fit is weak for IPPRA’s portfolio. Public universities are eligible, but the NOFO is not a natural anchor for IPPRA beyond a limited supporting role. |