High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed)
NIH funds purchase or upgrade of a single high-end, commercially available instrument or integrated system for groups of NIH-supported investigators, up to $2,000,000.
⚑ Clinical trials not allowed · Foreign organizations and foreign components are not allowed · Award is for equipment/instrument purchase or upgrade, not research activities · Minimum award $750,001; maximum award $2,000,000
Unit fits — one characterization, each unit's own rules
| Physical Sciences & Engineering (demo) | 50 partial | technical depth: substantial; funds construction equipment (capped) |
| Tom Love Innovation Hub | 30 weak | prototyping/demonstration stage; deep-tech content |
| IPPRA | 23 weak | outside portfolio topics; social/behavioral work is minor; funds construction equipment — not a research fit; biomedical core — IPPRA health lane is communication/crisis/policy (capped) |
Description
The High-End Instrumentation (HEI) Grant Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-end, specialized, commercially available instruments or integrated systems. The minimum award is $750,001. There is no maximum price limit for the instrument; however, the maximum award is $2,000,000. Instruments supported include, but are not limited to, nuclear magnetic resonance spectrometers, X-ray diffractometers, mass spectrometers, high throughput robotic screening systems, DNA and protein sequencers, biosensors, electron and light microscopes, flow cytometers, and biomedical imagers.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Apply
View on Grants.gov → CONTACT: National Institutes of Health <grantsinfo@nih.gov>
Proposal brief SEE AN EXAMPLE →
A one-page internal memo: fit assessment, submission requirements, document scaffold, and next steps dated back from the deadline — tailored to your project idea if you add one.
Proposal shell · National Institutes of Health conventions SEE AN NIH EXAMPLE →
Funder-faithful document skeletons — National Institutes of Health's document set with section headings, page limits, reviewer guidance, and writing prompts; add a project idea to get [DRAFT] starter bullets. Download as .md for Word or Overleaf.