NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required)
NIH funding supports multi-center cooperative clinical trials on neurological emergencies conducted within the SIREN Network, with trial coordination and data/statistical support provided by NIH infrastructure.
⚑ Clinical trial required. · UG3/UH3 cooperative agreement with NIH SIREN CCC/DCC and network hubs providing core trial infrastructure. · Stroke treatment/recovery/prevention trials supported by NINDS are directed to NIH StrokeNet, not SIREN. · Foreign organizations are allowed; applicants do not need to already be part of SIREN.
Unit fits — one characterization, each unit's own rules
| Physical Sciences & Engineering (demo) | 70 strong | technical depth: substantial; funds applied research |
| IPPRA | 58 good | portfolio topics: public_health, emergency_disaster_resilience; social/behavioral work is minor; funds applied research; clinical-trial/biomedical core — IPPRA angle is policy/community (capped) |
| Tom Love Innovation Hub | 30 weak | funds applied research; deep-tech content |
Description
This announcement (NOFO) encourages applications for multi-center clinical trials focused on neurological emergencies. Successful applicants will collaborate and conduct the trial within the NIH SIREN Network. The NIH SIREN Clinical Coordinating Center (CCC) will work with the successful applicants to implement the proposed trial efficiently and the SIREN Data Coordinating Center (DCC) will provide statistical and data management support. The NIH SIREN hubs and their affiliated clinical sites will provide on-site implementation of the clinical protocols.The NIH SIREN Network will also be uniquely poised to collaborate with other US and international consortia necessary to conduct larger, definitive trials of promising interventions for neurological emergencies.Multi-center clinical trials in stroke treatment, recovery, or prevention supported by NINDS will be conducted in the NIH StrokeNet, and not within SIREN. Applicants do not need to be part of the existing SIREN infrastructure to apply under this FOA.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Apply
View on Grants.gov → CONTACT: National Institutes of Health <grantsinfo@nih.gov>
Proposal brief
Proposal shell · National Institutes of Health conventions
Legacy IPPRA LLM assessment (v2.0, for comparison)
18/100 · gpt-5.4-mini · 2026-07-06
This is a neuroscience clinical-trial cooperative agreement focused on neurological emergencies, which is primarily biomedical and operational rather than a social-science, policy, or behavioral research opportunity. While the topic sits within public health/crisis response in a broad sense, the NOFO is for multi-center clinical trials with NIH network implementation support, and does not meaningfully center the kinds of communication, community, or policy research IPPRA leads. Public universities are eligible, but the fit for IPPRA is still weak because it is not an institute-strength research area and is not aligned with the human-side systems work in the portfolio.
Legacy scoring history
| 2026-07-06 | 18 | gpt-5.4-mini | This is a neuroscience clinical-trial cooperative agreement focused on neurological emergencies, which is primarily biomedical and operational rather than a social-science, policy, or behavioral research opportunity. While the topic sits within public health/crisis response in a broad sense, the NOFO is for multi-center clinical trials with NIH network implementation support, and does not meaningfully center the kinds of communication, community, or policy research IPPRA leads. Public universities are eligible, but the fit for IPPRA is still weak because it is not an institute-strength research area and is not aligned with the human-side systems work in the portfolio. |
| 2026-07-06 | 52 | gpt-5.4-mini | This is a strong public-health fit because it supports multi-center clinical trials for neurological emergencies, with clear relevance to crisis response, patient outcomes, and clinical decision-making. However, it is predominantly a biomedical/clinical trials NOFO rather than a behavioral, communication, or policy research opportunity, so IPPRA would be more likely a supporting collaborator than a lead. Public universities are eligible, so there is no eligibility cap issue. |