Social disconnection and Suicide Risk in Late Life (R21 Clinical Trial Optional)
NIH R21 grants supporting late-life suicide research on social disconnection, including mechanisms, experimental therapeutics, and intervention or service-delivery models to improve social connection and prevent suicide.
⚑ Clinical Trial Optional · R21 mechanism · No award ceiling listed in notice ($0 shown)
This is a late-life suicide/clinical mental health opportunity centered on neurobiological mechanisms, intervention development, and service delivery models, which is outside IPPRA’s core survey/risk-communication/public-opinion program. The team might understand the social-isolation or risk-perception angle, but this is not plausibly a PI-level fit for any listed member.
JUDGED AGAINST THE ROSTER'S PUBLICATION DOSSIER · GPT-5.4-MINI · 2026-07-07
Unit fits — one characterization, each unit's own rules
| IPPRA | 58 good | portfolio topic: public_health (primary); signature methods: surveys longitudinal, community engaged, policy analysis; social/behavioral work is central; funds applied research; biomedical core — IPPRA health lane is communication/crisis/policy (capped); clinical-trial/biomedical core — IPPRA angle is policy/community (capped) |
| Physical Sciences & Engineering (demo) | 55 good | technical depth: minor; funds applied research |
| Tom Love Innovation Hub | 30 weak | funds applied research; deep-tech content |
Description
This initiative seeks to solicit applications for research projects that address the link between social disconnection including both objective social isolation as well as perceived social isolation (otherwise known as loneliness) and suicide in late-life. Emphasis is placed on research that identifies neurobiological and environmental mechanisms associated with social isolation and loneliness that increase risk for suicidal thoughts and behavior in late-life, that uses an experimental therapeutics approach to identify targets and develop and test interventions to prevent late-life suicide, and that develops new and modifies existing service delivery models to enhance social connection in late-life to prevent suicide.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Apply
View on Grants.gov → CONTACT: National Institutes of Health <grantsinfo@nih.gov>
Proposal brief SEE AN EXAMPLE →
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Proposal shell · National Institutes of Health conventions SEE AN NIH EXAMPLE →
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