IPPRA / Grant Monitor

2026-07-07
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Social disconnection and Suicide Risk in Late Life (R21 Clinical Trial Optional)

PAR-25-066 · National Institutes of Health

public health mental behavioral health biomedical clinical Health

Closes
2026-09-07 · 62 d
Award ceiling
Award floor
Program funding
Expected awards
Cost sharing
No
Posted
2024-11-18
Instrument
Grant
Characterization · gpt-5.4-mini · 2026-07-07

NIH R21 grants supporting late-life suicide research on social disconnection, including mechanisms, experimental therapeutics, and intervention or service-delivery models to improve social connection and prevent suicide.

Funds
applied research
University
direct
social behavioral
central
life biomedical
central
computational data
minor

⚑ Clinical Trial Optional · R21 mechanism · No award ceiling listed in notice ($0 shown)

Unit fits — one characterization, each unit's own rules

IPPRA 58 good portfolio topics: public_health, mental_behavioral_health (primary); social/behavioral work is central; funds applied research; clinical-trial/biomedical core — IPPRA angle is policy/community (capped)
Physical Sciences & Engineering (demo) 55 good technical depth: minor; funds applied research
Tom Love Innovation Hub 30 weak funds applied research; deep-tech content

Description

This initiative seeks to solicit applications for research projects that address the link between social disconnection including both objective social isolation as well as perceived social isolation (otherwise known as loneliness) and suicide in late-life. Emphasis is placed on research that identifies neurobiological and environmental mechanisms associated with social isolation and loneliness that increase risk for suicidal thoughts and behavior in late-life, that uses an experimental therapeutics approach to identify targets and develop and test interventions to prevent late-life suicide, and that develops new and modifies existing service delivery models to enhance social connection in late-life to prevent suicide.

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Apply

View on Grants.gov → CONTACT: National Institutes of Health <grantsinfo@nih.gov>

Proposal brief

ONE LLM CALL (~1¢) · CACHED · REQUIRES STAFF KEY

Proposal shell · National Institutes of Health conventions

ONE LLM CALL (~2-3¢) · CACHED · SCAFFOLDING, NOT GHOSTWRITING