IPPRA / Grant Monitor

2026-07-07
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Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R21 Clinical Trial Optional)

PAR-25-064 · National Institutes of Health

biomedical clinical mental behavioral health public health Health

Closes
2026-09-07 · 62 d
Award ceiling
Award floor
Program funding
Expected awards
Cost sharing
No
Posted
2024-11-18
Instrument
Grant
Characterization · gpt-5.4-mini · 2026-07-07

NIH R21 grants to support mechanistic studies of neuropsychiatric symptoms in Alzheimer’s disease or related dementias, including work that may identify novel therapeutic targets for future interventions.

Funds
basic research
University
direct
social behavioral
substantial
life biomedical
central
computational data
minor

⚑ Clinical Trial Optional · R21 mechanism · foreign organizations and several other nontraditional entities are eligible · focused on mechanism rather than treatment delivery

Unit fits — one characterization, each unit's own rules

IPPRA 58 good portfolio topics: mental_behavioral_health, public_health; social/behavioral work is substantial; funds basic research; clinical-trial/biomedical core — IPPRA angle is policy/community (capped)
Physical Sciences & Engineering (demo) 55 good technical depth: minor; funds basic research
Tom Love Innovation Hub 15 none deep-tech content; no commercialization signal

Description

The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies that will enhance knowledge of mechanisms associated with neuropsychiatric symptoms (NPS) in persons with Alzheimer's disease (AD) or Alzheimer's disease-related dementias (ADRD). The findings are expected to advanceadavnce mechanistic understanding of both biobehavioral and neurobiologfical pathways leading to NPS. Findings may also provide insight into novel therapeutic targets that can be advanced into interventions to treat and prevent the development of NPS in AD and/or ADRD.

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Apply

View on Grants.gov → CONTACT: National Institutes of Health <grantsinfo@nih.gov>

Proposal brief

ONE LLM CALL (~1¢) · CACHED · REQUIRES STAFF KEY

Proposal shell · National Institutes of Health conventions

ONE LLM CALL (~2-3¢) · CACHED · SCAFFOLDING, NOT GHOSTWRITING