IPPRA / Grant Monitor

2026-07-07
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Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)

PAR-25-068 · National Institutes of Health

biomedical clinical public health social services Food and Nutrition Health

Closes
2027-11-16 · 497 d
Award ceiling
Award floor
Program funding
Expected awards
Cost sharing
No
Posted
2025-01-08
Instrument
Grant
Characterization · gpt-5.4-mini · 2026-07-07

This NOFO funds innovative basic and translational pilot studies on biological, behavioral, and social mechanisms related to HIV pathogenesis and NIDDK-relevant HIV comorbidities, coinfections, complications, and reservoirs.

Funds
basic research
University
direct
social behavioral
substantial
physical sciences
minor
life biomedical
central
computational data
minor

⚑ R21 pilot studies; clinical trials not allowed · Foreign organizations are explicitly not eligible, but foreign components of U.S. organizations are allowed · No award ceiling stated in the notice excerpt (listed as $0)

Unit fits — one characterization, each unit's own rules

IPPRA 84 strong portfolio topic: public_health; social/behavioral work is substantial; funds basic research
Physical Sciences & Engineering (demo) 55 good technical depth: minor; funds basic research
Tom Love Innovation Hub 15 none deep-tech content; no commercialization signal

Description

This Notice of Funding Opportunity (NOFO) invites applications for innovative basic and translational pilot research projects within the mission of the NIDDK that are aligned with NIH HIV/AIDS research priorities. These priorities were most recently outlined by the NIH Office of AIDS Research (OAR) in NOT-20-018, UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding, scientific priorities. Potential topics could address multiple overarching priorities. These include elucidation of unique pathophysiological mechanisms contributing to HIV comorbidities, coinfections, and complications (CCCs) affecting organs, tissues, and processes within the mission of the NIDDK. Likewise, interrogations into biological mechanisms underlying HIV reservoirs in NIDDK-relevant tissues are important for developing strategies for long-term viral suppression or eradication. Finally, health-impeding social determinants of health may affect CCCs or viral reservoirs within NIDDK's mission through multiple pathways.

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Apply

View on Grants.gov → CONTACT: National Institutes of Health <grantsinfo@nih.gov>

Proposal brief

ONE LLM CALL (~1¢) · CACHED · REQUIRES STAFF KEY

Proposal shell · National Institutes of Health conventions

ONE LLM CALL (~2-3¢) · CACHED · SCAFFOLDING, NOT GHOSTWRITING