Single Source: Cardiothoracic Surgical Trials Network (CTSN) Data Coordinating Center (U01 Clinical Trial Required)
This single-source NIH cooperative agreement funds the Icahn School of Medicine at Mount Sinai to operate the Cardiothoracic Surgical Trials Network Data Coordinating Center, including trial coordination, data management, statistical analysis, long-term follow-up, and a central clinical/implementation research scholars program.
RESTRICTED TO: SINGLE NAMED INSTITUTION
⚑ Single-source competition; only Icahn School of Medicine at Mount Sinai may apply. · Multi-PD/PI application strongly encouraged (DMAC and CCC leadership). · Clinical trial required; DCC supports multiple randomized clinical trials. · Foreign organizations and non-domestic components of U.S. organizations are not eligible; foreign components are allowed.
Unit fits — one characterization, each unit's own rules
| IPPRA | 5 none | limited competition — a named institution holds this |
| Tom Love Innovation Hub | 5 none | not openly competed |
| Physical Sciences & Engineering (demo) | 5 none | limited competition — a named institution holds this |
Description
This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from the eligible organization to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application will be peer-reviewed, and if it is not a meritorious application, it will not be funded. This single source NOFO is intended to support a Data Coordinating Center (DCC) to conduct the activities of the Cardiothoracic Surgical Trials Network (CTSN). The DCC will consist of two collaborating components including a Data Management and Analytics Center (DMAC) and a Clinical Coordination Center (CCC). NHLBI strongly encourages multi-PD/PI applications with two PDs/PIs; one PD/PI for the DMAC and one PD/PI for the CCC. The primary responsibility of the DCC is to oversee the conduct of multiple randomized clinical trials in the CTSN.The DCC will support regulatory and administrative activities, data collection and management, and statistical analysis and reporting of trial results in a timely manner. The DCC will promote collaboration and communication among CTSN investigators and the broader research community and will coordinate outreach activities including engaging foundations, research entities, and small businesses in trials of mutual interest and public health importance. The DCC is responsible for integrating the efforts of clinical sites, core laboratories, and other collaborators, and conducting long-term follow-up centrally via telephone follow-up at the DCC. The NHLBI anticipates that the DCC will manage a Clinical and Implementation Research Skills Program centrally. The clinical and implementation research scholars program will support the expanded integration of clinical skills with dissemination and implementation science scholarship to enhance implementation research capacity. The scholars program would be designed to foster additional research questions within CTSN as well as generate a cohort of researchers who would transport their scholarship as they transition to leadership positions in academic and clinical programs.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Only the following applicant is eligible to apply for this single source funding: Icahn School of Medicine at Mount Sinai. Please refer to Section I. Notice of Funding Opportunity Information for more details.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Apply
View on Grants.gov → CONTACT: National Institutes of Health <NHLBI_CTSN@nhlbi.nih.gov>
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Legacy IPPRA LLM assessment (v2.0, for comparison)
18/100 · gpt-5.4-mini · 2026-07-06
This is a highly specialized NIH data coordinating center for randomized cardiothoracic surgical trials, focused on trial operations, data management, and statistical analysis rather than IPPRA’s core human-behavior, policy, or survey research domains. While it includes a clinical/implementation research skills program and long-term follow-up, the opportunity is restricted to Icahn School of Medicine at Mount Sinai, so a public university like OU would be ineligible and the score is capped very low.
Legacy scoring history
| 2026-07-06 | 18 | gpt-5.4-mini | This is a highly specialized NIH data coordinating center for randomized cardiothoracic surgical trials, focused on trial operations, data management, and statistical analysis rather than IPPRA’s core human-behavior, policy, or survey research domains. While it includes a clinical/implementation research skills program and long-term follow-up, the opportunity is restricted to Icahn School of Medicine at Mount Sinai, so a public university like OU would be ineligible and the score is capped very low. |
| 2026-07-06 | 3 | gpt-5.4-mini | This is a highly specialized NIH single-source cooperative agreement for the CTSN Data Coordinating Center, focused on managing and analyzing cardiothoracic clinical trials. While it includes implementation science training and long-term follow-up, the topic is predominantly clinical/biomedical rather than IPPRA’s social science, policy, or risk-communication strengths. It is also not eligible for a public university applicant, as only Icahn School of Medicine at Mount Sinai may apply, so the score is capped very low. |