Assessing the Feasibility of Incorporating Mechanisms in Multi-site Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration (R33 Clinical Trial Required)
NIH/NCCIH will fund multi-site feasibility clinical trials of mind-and-body interventions that test whether the intervention can be delivered consistently and whether specified emotional well-being and whole-person health mechanisms and outcomes can be measured across sites.
⚑ Clinical trial required. · Foreign organizations, non-domestic components of U.S. organizations, and foreign components are not allowed. · R33 feasibility/early-phase mechanism-focused multi-site trial; award ceiling $500,000. · Applicants should expect strict multi-site fidelity, recruitment/retention, randomization, and mechanistic data-collection feasibility aims.
This is a biomedical/clinical multi-site trial program on mind-body interventions and whole-person health mechanisms, which is far outside IPPRA’s core lines in public risk, hazard communication, energy, and education policy evaluation. Even though it involves evaluation and feasibility, it is clinical medicine rather than the team’s social-science program.
JUDGED AGAINST THE ROSTER'S PUBLICATION DOSSIER · GPT-5.4-MINI · 2026-10-16
Unit fits — one characterization, each unit's own rules
| IPPRA | 58 good | evaluation research with education outcomes (core line, secondary); social/behavioral work is substantial; funds evaluation research; biomedical core — IPPRA health lane is communication/crisis/policy (capped); clinical-trial/biomedical core — IPPRA angle is policy/community (capped) |
| Physical Sciences & Engineering (demo) | 40 partial | technical depth: substantial; funds evaluation research (capped) |
| Tom Love Innovation Hub | 15 none | deep-tech content; no commercialization signal |
Description
The National Center for Complementary and Integrative Health (NCCIH) announces this Notice of Funding Opportunity (NOFO) to solicit applications for multi-site feasibility trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) to reproduce and translate mechanisms of emotional well-being (EWB) into large-scale clinical trials that advance our understanding of whole person health. These early-phase multi-site trials are essential for 1) demonstrating that the mind and body intervention can be delivered with fidelity across sites; 2) demonstrating reproducibility and rigor in engaging targeted mechanisms of EWB by the mind and body intervention across sites; 3) assessing feasibility of participant recruitment and retention, as well as randomization; 4) assessing feasibility of collecting comprehensive clinical (whole person health restoration) and mechanistic (EWB) data across sites; and 5) exploring correlations between changes in mechanistic targets and clinical outcome measurements pooled across sites. By laying this groundwork, studies supported under this NOFO will advance the science of whole person health and prepare the field for rigorous clinical trials and mechanistic mediation analysis with the potential to improve the health and well-being of all Americans.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Apply
View on Grants.gov → CONTACT: National Institutes of Health <NCCIHDERFunding@nih.gov>
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