Single Source: HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Data Translation Center (U54 Clinical Trial Optional)
A single-source NIH cooperative agreement to Northwestern University for the HeartShare Data Translation Center to coordinate the program, curate and analyze HFpEF phenotyping data, and support planning and data analysis for clinical trials.
RESTRICTED TO: SINGLE NAMED INSTITUTION
⚑ Single-source notice: only Northwestern University may apply · Foreign organizations/international collaborations not eligible; foreign components not allowed · One award intended if application is meritorious · Companion NOFO supports clinical centers and a clinical trial center
Unit fits — one characterization, each unit's own rules
| IPPRA | 5 none | limited competition — a named institution holds this |
| Tom Love Innovation Hub | 5 none | not openly competed |
| Physical Sciences & Engineering (demo) | 5 none | limited competition — a named institution holds this |
Description
This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invites an application from an eligible organization to apply. Please see Section III. Eligibility for additional information. The NHLBI is announcing its intent to issue a single source cooperative agreement to Northwestern University. This NOFO solicits a renewal of the Data Translation Center for an ongoing NHLBI phenomics program, HeartShare, to coordinate the overall project, continue to oversee enrollment of a cohort of patients with heart failure with preserved ejection fraction (HFpEF), curate and analyze prospective deep phenotyping data, and support planning, implementation, and data analysis for clinical trials. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered.Companion NOFO RFA-HL-27-008 will support Clinical Centers for recruitment and follow-up of heart failure patients and a Clinical Trial Center for new clinical trial activities.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibilityThis is a non-competitive funding opportunity intended, if the peer-reviewed application is meritorious, to fund a single award. Only the following applicant is eligible to apply for this single source funding: Northwestern University.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Apply
View on Grants.gov → CONTACT: National Institutes of Health <nhlbiheartshare@mail.nih.gov>
Proposal brief SEE AN EXAMPLE →
A one-page internal memo: fit assessment, submission requirements, document scaffold, and next steps dated back from the deadline — tailored to your project idea if you add one.
Proposal shell · National Institutes of Health conventions SEE AN NIH EXAMPLE →
Funder-faithful document skeletons — National Institutes of Health's document set with section headings, page limits, reviewer guidance, and writing prompts; add a project idea to get [DRAFT] starter bullets. Download as .md for Word or Overleaf.
Legacy IPPRA LLM assessment (v2.0, for comparison)
0/100 · gpt-5.4-mini · 2026-07-06
This is a single-source NIH cooperative agreement reserved for Northwestern University only, so a public university like the University of Oklahoma is not eligible to apply or serve as a named research partner. The topic is cardiovascular phenotyping and clinical trial coordination, which is also outside IPPRA’s core behavioral/policy portfolio except for a very indirect health-research link.
Legacy scoring history
| 2026-07-06 | 0 | gpt-5.4-mini | This is a single-source NIH cooperative agreement reserved for Northwestern University only, so a public university like the University of Oklahoma is not eligible to apply or serve as a named research partner. The topic is cardiovascular phenotyping and clinical trial coordination, which is also outside IPPRA’s core behavioral/policy portfolio except for a very indirect health-research link. |
| 2026-07-06 | 0 | gpt-5.4-mini | This is a single-source NIH cooperative agreement restricted to Northwestern University, so a public university like OU/IPPRA cannot apply or participate as a named lead. The topic is also highly biomedical and focused on heart failure phenotyping and clinical trial infrastructure, with no meaningful public policy, behavioral, or community-risk communication component for IPPRA. |