Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)
NIH/NIDA will support cooperative-agreement research to build and use a multimodal inventory of neural cell ensembles encoding the effects of addictive substances and related behavioral states.
⚑ U01 cooperative agreement · Clinical Trial Not Allowed · foreign organizations may apply, but applications with foreign subawards/subcontracts are noncompliant · renewal/expansion of an existing collaboratory program; check NOFO eligibility details
This is a basic neuroscience/NIDA collaboratory on neural ensembles and addiction biology, which is far outside IPPRA’s social-behavioral program lines. The team’s closest expertise is public health/behavioral policy, not cellular or multimodal brain mapping, so it would not plausibly be pursued by a member as PI.
JUDGED AGAINST THE ROSTER'S PUBLICATION DOSSIER · GPT-5.4-MINI · 2026-10-10
Unit fits — one characterization, each unit's own rules
| Physical Sciences & Engineering (demo) | 90 strong | technical depth: central; funds basic research |
| IPPRA | 48 partial | outside portfolio topics; social/behavioral work is minor; funds basic research; biomedical core — IPPRA health lane is communication/crisis/policy (capped) |
| Tom Love Innovation Hub | 15 none | deep-tech content; no commercialization signal |
Description
The National Institute on Drug Abuse (NIDA) invites applications to renew and expand the Collaboratory on Neural Ensembles and Used Substances (NExUS).
NExUS is a collaborative research program to decode how substance use experiences and addictive neurobehavioral states are represented in the brain at the level of cell populations.
This funding opportunity seeks applications that propose systematic and scalable methods to identify, map, and analyze groups of neurons that respond to used substances. The goal is to create a comprehensive, multimodal database and use it to test hypotheses about how specific neural population activity patterns relate to behavioral states associated with substance use and substance use disorders (SUD), including intoxication, craving, and dependence.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibilityForeign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Apply
View on Grants.gov → CONTACT: National Institutes of Health <INBranch_NIDA@nih.gov>
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