Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50 Clinical Trial Optional)
Supports integrative, high-risk basic neuroscience or translational mental health research teams studying mechanisms of brain, behavior, and psychopathology for eligible U.S. applicants under NIH/NIMH rules.
⚑ P50 center mechanism; clinical trial optional · Foreign organizations and foreign components are not allowed · Intended for projects not achievable with standard grant mechanisms · High-risk/high-impact, integrative team science
This is a basic/translational neuroscience and mental health center program, which is far outside IPPRA’s survey, risk-perception, policy evaluation, weather, energy, and public-opinion lines. The team could only be peripherally involved through very indirect behavioral methods, but none of the roster has a substantive neuroscience or clinical psychopathology program.
JUDGED AGAINST THE ROSTER'S PUBLICATION DOSSIER · GPT-5.4-MINI · 2026-09-02
Unit fits — one characterization, each unit's own rules
| Physical Sciences & Engineering (demo) | 80 strong | technical depth: substantial; funds basic research |
| IPPRA | 58 good | outside portfolio topics; social/behavioral work is central; funds basic research; biomedical core — IPPRA health lane is communication/crisis/policy (capped); clinical-trial/biomedical core — IPPRA angle is policy/community (capped) |
| Tom Love Innovation Hub | 15 none | deep-tech content; no commercialization signal |
Description
This notice of funding opportunity (NOFO) encourages applications for Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research. The National Institute of Mental Health (NIMH) seeks teams of integrative researchers working at different levels of analysis and employing novel, and creative experimental approaches to address high-risk, high-impact questions with the primary objectives of: (a) advancing basic brain and behavior research that will uncover underlying mechanisms that could provide the foundation for understanding mental disorders; (b) supporting the integration and translation of basic and clinical neuroscience research on severe mental illnesses; (c) advancing our understanding of the neurobehavioral mechanisms and trajectories of psychopathology that begin in development. This program is intended only for projects that could not be achieved using other, more standard grant mechanisms.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Apply
View on Grants.gov → CONTACT: National Institutes of Health <DNBBSinitiatives@mail.nih.gov>
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