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2026-07-07
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INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)

RFA-OD-27-003 · National Institutes of Health

biomedical clinical mental behavioral health ai data science public health Health

Closes
2028-06-15 · 709 d
Award ceiling
$200,000
Award floor
Program funding
$1,000,000
Expected awards
5
Cost sharing
No
Posted
2026-05-12
Instrument
Grant
Characterization · gpt-5.4-mini · 2026-07-07

NIH funds exploratory/developmental research projects on Down syndrome under the INCLUDE Project for eligible applicants, excluding clinical trials.

Funds
basic research
University
direct
social behavioral
substantial
engineering
minor
life biomedical
central
computational data
minor

⚑ R21 exploratory/developmental mechanism · Clinical Trial Not Allowed · foreign organizations and foreign components are allowed · award ceiling $200,000

Unit fits — one characterization, each unit's own rules

IPPRA 84 strong portfolio topics: mental_behavioral_health, public_health; social/behavioral work is substantial; funds basic research
Physical Sciences & Engineering (demo) 65 good technical depth: minor; funds basic research
Tom Love Innovation Hub 15 none deep-tech content; no commercialization signal

Description

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of new exploratory and developmental research projects that address critical needs for Down syndrome projects, as articulated in the INCLUDE Project objectives. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Apply

View on Grants.gov → CONTACT: National Institutes of Health <DownSyndromeINCLUDE@mail.nih.gov>

Proposal brief

ONE LLM CALL (~1¢) · CACHED · REQUIRES STAFF KEY

Proposal shell · National Institutes of Health conventions

ONE LLM CALL (~2-3¢) · CACHED · SCAFFOLDING, NOT GHOSTWRITING