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2026-07-07
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INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

RFA-OD-27-004 · National Institutes of Health

biomedical clinical public health mental behavioral health ai data science Health

Closes
2028-06-15 · 709 d
Award ceiling
$500,000
Award floor
Program funding
$3,000,000
Expected awards
4
Cost sharing
No
Posted
2026-05-12
Instrument
Grant
Characterization · gpt-5.4-mini · 2026-07-07

NIH will fund highly innovative, transformative research on Down syndrome or its co-occurring conditions for eligible applicants, with no preliminary data required and clinical trials not allowed.

Funds
basic research
University
direct
social behavioral
substantial
physical sciences
minor
engineering
minor
life biomedical
central
computational data
substantial

⚑ R01 Clinical Trial Not Allowed · award ceiling $500,000 · foreign organizations and foreign components allowed · no preliminary data required

Unit fits — one characterization, each unit's own rules

IPPRA 84 strong portfolio topics: public_health, mental_behavioral_health; social/behavioral work is substantial; funds basic research
Physical Sciences & Engineering (demo) 80 strong technical depth: substantial; funds basic research
Tom Love Innovation Hub 15 none deep-tech content; no commercialization signal

Description

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Apply

View on Grants.gov → CONTACT: National Institutes of Health <DownSyndromeINCLUDE@mail.nih.gov>

Proposal brief

ONE LLM CALL (~1¢) · CACHED · REQUIRES STAFF KEY

Proposal shell · National Institutes of Health conventions

ONE LLM CALL (~2-3¢) · CACHED · SCAFFOLDING, NOT GHOSTWRITING