INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)
NIH will fund highly innovative, transformative research on Down syndrome or its co-occurring conditions for eligible applicants, with no preliminary data required and clinical trials not allowed.
⚑ R01 Clinical Trial Not Allowed · award ceiling $500,000 · foreign organizations and foreign components allowed · no preliminary data required
This is a biomedical/clinical Down syndrome mechanism and intervention call, which is far outside IPPRA’s survey, risk perception, warning communication, and policy-evaluation portfolio. Even though the NOFO allows broad innovation and some public-health framing, it is not a plausible PI-level fit for this team.
JUDGED AGAINST THE ROSTER'S PUBLICATION DOSSIER · GPT-5.4-MINI · 2026-07-07
Unit fits — one characterization, each unit's own rules
| Physical Sciences & Engineering (demo) | 80 strong | technical depth: substantial; funds basic research |
| IPPRA | 58 good | peripheral portfolio topic: public_health; social/behavioral work is substantial; funds basic research; biomedical core — IPPRA health lane is communication/crisis/policy (capped) |
| Tom Love Innovation Hub | 15 none | deep-tech content; no commercialization signal |
Description
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Apply
View on Grants.gov → CONTACT: National Institutes of Health <DownSyndromeINCLUDE@mail.nih.gov>
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