Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)
This NIH program funds U.S. eligible institutions to buy a single commercially available biomedical research instrument that is not already available at the institution and will be shared to expand research capacity.
⚑ Purchase of a single commercially available instrument only; shared-use requirement. · Maximum award $400,000; minimum award $50,000. · Clinical trials not allowed. · Foreign organizations and foreign components are not allowed.
Unit fits — one characterization, each unit's own rules
| Physical Sciences & Engineering (demo) | 50 partial | technical depth: substantial; funds construction equipment (capped) |
| Tom Love Innovation Hub | 30 weak | prototyping/demonstration stage; deep-tech content |
| IPPRA | 23 weak | outside portfolio topics; social/behavioral work is minor; funds construction equipment — not a research fit; biomedical core — IPPRA health lane is communication/crisis/policy (capped) |
Description
This Notice of Funding Opportunity (NOFO) aims to build new research capacity and develop a sustainable research program by supporting the purchase of a single commercially available biomedical research instrument currently unavailable in the institution. Instruments funded through this program must be shared among the users to create new research opportunities, enable reproducible data generation, encourage collaborative research and training, and strengthen long-term research capabilities. The minimum award is $50,000. While there is no limit on the total cost of the instrument, the maximum award is $400,000.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Apply
View on Grants.gov → CONTACT: National Institutes of Health <odsig@mail.nih.gov>
Proposal brief SEE AN EXAMPLE →
A one-page internal memo: fit assessment, submission requirements, document scaffold, and next steps dated back from the deadline — tailored to your project idea if you add one.
Proposal shell · National Institutes of Health conventions SEE AN NIH EXAMPLE →
Funder-faithful document skeletons — National Institutes of Health's document set with section headings, page limits, reviewer guidance, and writing prompts; add a project idea to get [DRAFT] starter bullets. Download as .md for Word or Overleaf.