Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO)
ARPA-H’s Health Science Futures ISO funds solution summaries and proposals for cutting-edge, disease-agnostic health science projects with potential for translational real-world impact.
⚑ Federal contract/other transaction solicitation through ARPA-H; not a standard grant. · Amendment 2 applies to new proposal submissions and updates required attachments/templates. · Solution summaries and proposals are submitted through the ARPA-H online portal. · No cooperative agreements available under this amendment.
Unit fits — one characterization, each unit's own rules
| Physical Sciences & Engineering (demo) | 75 strong | technical depth: central; funds applied research |
| IPPRA | 53 partial | peripheral portfolio topic: public_health; social/behavioral work is minor; funds applied research; eligibility unclear — verify in the NOFO; biomedical core — IPPRA health lane is communication/crisis/policy (capped) |
| Tom Love Innovation Hub | 45 partial | funds applied research; prototyping/demonstration stage; deep-tech content |
Description
This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 2 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the base solicitation will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The amendment: Updated solutions summary template; Updated bundle of attachments for other transactions (admin & national policy requirements document, cost proposal narrative, cost proposal workbook, task description document, and technical & management proposal) for proposal submissions; Removed cooperative agreements as a potential award instrument and removed bundle of attachments for cooperative agreements; Updated various sections of the ISO.
Eligibility
Applicant restrictions (federal contract). Set-aside: . Notice type: Solicitation. Organization: HEALTH AND HUMAN SERVICES, DEPARTMENT OF / NATIONAL INSTITUTES OF HEALTH / ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H).
Apply
Proposal brief SEE AN EXAMPLE →
A one-page internal memo: fit assessment, submission requirements, document scaffold, and next steps dated back from the deadline — tailored to your project idea if you add one.
Proposal shell · HHS services agencies (SAMHSA / HRSA / CDC / ACF) conventions SEE AN HHS EXAMPLE →
Funder-faithful document skeletons — HHS services agencies (SAMHSA / HRSA / CDC / ACF)'s document set with section headings, page limits, reviewer guidance, and writing prompts; add a project idea to get [DRAFT] starter bullets. Download as .md for Word or Overleaf.