National Cancer Institute (NCI) Small Business Innovation Research (SBIR) Innovative Concept Award Program – Fiscal Year 2027
NCI will fund eligible small businesses to develop and de-risk highly innovative cancer-related therapeutic, preventive, diagnostic, device, or digital health technologies for pediatric cancers and/or rare cancers, with commercialization planning required.
RESTRICTED TO: SMALL BUSINESS SBIR STTR
⚑ SBIR total small business set-aside; public universities cannot apply as prime · expects proof-of-concept/de-risking data; preliminary data not required · includes entrepreneurial skills, business model, and commercialization plan requirements · water paper/interim concept submission expected before final deadline
Unit fits — one characterization, each unit's own rules
| Tom Love Innovation Hub | 100 strong | SBIR/STTR — core Hub pipeline (faculty founders + small-business partners); funds commercialization; prototyping/demonstration stage; deep-tech content |
| Physical Sciences & Engineering (demo) | 35 weak | technical depth: substantial; funds commercialization (capped) |
| IPPRA | 25 weak | peripheral portfolio topic: public_health; social/behavioral work is minor; funds commercialization — not a research fit; university can only partner, not lead; biomedical core — IPPRA health lane is communication/crisis/policy (capped); clinical-trial/biomedical core — IPPRA angle is policy/community (capped) |
Description
Description The National Cancer Institute (NCI) is soliciting proposals from small business concerns to perform key activities to demonstrate technical feasibility and proof-of-concept for the development of highly innovative and potentially transformative technologies in the following areas: Topic 1: Development of therapeutic or preventative technologies for treatment or prevention of Pediatric Cancers and/or Rare Cancers. Topic 2: Development of devices, diagnostic technologies, or digital health tools for treatment, detection, and diagnosis of Pediatric Cancers and/or Rare Cancers. For this solicitation, rare cancers with a 5-year survival rate of less than 50% are encouraged, and rare cancers include all the cancers listed by the NIH Genetics and Rare Diseases Information Center. For the purposes of this solicitation, a rare cancer is defined in accordance with the U.S. Food and Drug Administration (FDA) Orphan Drug Act as a malignancy with a total U.S. prevalence of fewer than 200,000 individuals. Prevalence estimates should be supported by authoritative data sources (e.g., SEER) or where direct estimates are not available, by scientifically justified epidemiologic approximations based on published literature. For more information regarding 5-year cancer survival rates, see the NCI Surveillance, Epidemiology, and End Results Program (SEER) database at: https://seer.cancer.gov/ Preliminary data is not required. However, the proposal must have a sound scientific premise, either based on the offeror's own research or literature evidence. Proposals shall both identify an anticipated product to be developed and clearly lay out the anticipated development path. Proposals must clearly identify the clinical problem and cancer type(s), along with adequate justification. In addition, offerors should propose experiments to obtain initial de-risking and proof-of-concept data. Awards will also include requirements to enhance entrepreneurial skills, to develop or refine a business model, and a commercialization plan. This Concept Award solicitation is intended to serve as a pipeline for the federal Small Business Innovation Research (SBIR) program. This is a total small business set-aside solicitation, and only proposals from eligible small businesses will be considered for award. This size standard is established by law for the SBIR program, regardless of the NAICS Code assigned. To be eligible as a small business, the offeror may have no more than 500 employees, including the employees of its affiliates (see 13 C.F.R. § 121.702). For other requirements, see the SBA's SBIR/STTR Policy Directive: https://www.sbir.gov/sites/default/files/SBA%20SBIR_STTR_POLICY_DIRECTIVE_May2023.pdf The solicitation for the NCI SBIR Innovative Concept Award Program is anticipated to be made available on or around July 17, 2026. This solicitation is expected to have a closing date in late September for receipt of proposals, with an interim deadline in June for submission and consideration of water papers. which will allow time for the NCI to provide feedback on whether the proposed idea falls within the scope of what this solicitation is seeking. Note – SBIR / STTR Grant Opportunities Other SBIR and STTR contract and grant opportunities are also available. Companies are encouraged to visit: https://seed.nih.gov/small-business-funding/find-funding For general information regarding the NCI SBIR Program, please refer to: https://sbir.cancer.gov/ Attachments/Links: No attachments or links have been added to this opportunity.
Eligibility
Applicant restrictions (federal contract). Set-aside: Total Small Business Set-Aside (FAR 19.5). Notice type: Presolicitation. Organization: HEALTH AND HUMAN SERVICES, DEPARTMENT OF / NATIONAL INSTITUTES OF HEALTH / NIH NCI.
Apply
Proposal brief SEE AN EXAMPLE →
A one-page internal memo: fit assessment, submission requirements, document scaffold, and next steps dated back from the deadline — tailored to your project idea if you add one.
Proposal shell · HHS services agencies (SAMHSA / HRSA / CDC / ACF) conventions SEE AN HHS EXAMPLE →
Funder-faithful document skeletons — HHS services agencies (SAMHSA / HRSA / CDC / ACF)'s document set with section headings, page limits, reviewer guidance, and writing prompts; add a project idea to get [DRAFT] starter bullets. Download as .md for Word or Overleaf.