High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)
DARPA is funding proposals to develop an in-silico platform for mapping protein-protein interactions and demonstrating its utility for identifying diagnostic and therapeutic targets, including in traumatic brain injury.
⚑ Federal contract solicitation; applicant restrictions apply, but the notice does not specify a limited class in the text provided. · Defense research topic with program-specific performance expectations; amendment updates attachment/sections of the PA. · Topic includes traumatic brain injury as an example application area.
This is a biomedical/AI computing program focused on protein-protein interactomics and diagnostic/therapeutic target discovery, which is far outside IPPRA’s core social-behavioral, risk-communication, education policy, and hazard-response lines. Even though DARPA is the sponsor, there’s no clear fit for any roster member as PI-level work.
JUDGED AGAINST THE ROSTER'S PUBLICATION DOSSIER · GPT-5.4-MINI · 2026-10-29
Unit fits — one characterization, each unit's own rules
| Physical Sciences & Engineering (demo) | 90 strong | technical depth: central; funds applied research |
| IPPRA | 40 partial | outside portfolio topics; social/behavioral work is none; funds applied research; biomedical core — IPPRA health lane is communication/crisis/policy (capped) |
| Tom Love Innovation Hub | 30 weak | funds applied research; deep-tech content |
Description
UPDATE: The purpose of Amendment 1 to DARPA-PA-27-01, the HUBBLE Program Announcement (PA), is to update Attachment B and the verbiage in Section 4.1.2 and Section 7.8 of the Program Announcement. The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury.
Eligibility
Applicant restrictions (federal contract). Set-aside: . Notice type: Solicitation. Organization: DEPT OF DEFENSE / DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) / DEF ADVANCED RESEARCH PROJECTS AGCY.
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