High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)
DARPA is funding proposals to build an in-silico system for mapping protein-protein interactions and demonstrating use of that capability to identify diagnostic and therapeutic targets, including for traumatic brain injury.
⚑ Federal contract solicitation; eligibility is governed by DARPA procurement rules rather than a standard grant competition. · Primary technical thrust is in-silico protein interaction mapping with biomedical target-identification demonstration. · No award ceiling stated.
This is primarily a biomedical/computational biology program aimed at protein interactomes and therapeutic target discovery, which is far outside IPPRA’s survey, risk, policy, education, and hazard-communication portfolio. The traumatic brain injury application does not make it a fit for this team’s PI-level research line.
JUDGED AGAINST THE ROSTER'S PUBLICATION DOSSIER · GPT-5.4-MINI · 2026-10-09
Unit fits — one characterization, each unit's own rules
| Physical Sciences & Engineering (demo) | 90 strong | technical depth: central; funds applied research |
| IPPRA | 40 partial | outside portfolio topics; social/behavioral work is none; funds applied research; biomedical core — IPPRA health lane is communication/crisis/policy (capped) |
| Tom Love Innovation Hub | 30 weak | funds applied research; deep-tech content |
Description
The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury.
Eligibility
Applicant restrictions (federal contract). Set-aside: . Notice type: Solicitation. Organization: DEPT OF DEFENSE / DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) / DEF ADVANCED RESEARCH PROJECTS AGCY.
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